bb rats การใช้

• Two T1D susceptibility genes have been identified in the BB rat.
• The Gimap5 mutation results in severe T cell lymphopenia in the BB rat and is thought to contribute to T1D pathogenesis through impaired development and function and regulatory T cells.
• Recently, 8 additional loci on rat chromosomes 1, 2, 3, 6 ( 2 loci ), 12 and 14 have been shown to be linked to Type 1 Diabetes in the BB rat.